CytoChip Cancer
CytoChip Cancer combines the precision of FISH with high resolution screening of copy number imbalance across the whole cancer genome. Automation ensures rapid delivery of objective results, direct from DNA, free of culturing artefacts in cells with as little as 30% tumour burden.
The updated (v2.0) CytoChip Cancer array design is highly enriched in disease regions and is exon-focused. Each CytoChip Cancer design includes more than 20,000 disease-targeted oligo probes, covering 670 cancer genes, including those which are typically amplified (HER-2/neu, MYC and EGFR), deleted (RB1, PTEN, BRCA1) and translocated (BCR-ABL, TMPRSS2, MLL) in cancers.
CytoChip Cancer is now available in three formats, 8x60K, 4x180K and 4x180K SNP. The 4x180K format combines 4 hybridizations per slide, each with 180K features, to support the highest resolution investigations. The 8x60K format provides a more cost effective combination of 8 hybridizations per slide, each with 60K features.
CytoChip Cancer SNP 4x180K includes 60,000 SNP probes distributed as evenly as possible across the genome to provide approximately 5 Mb LOH detection.
The three CytoChip Cancer formats provide differing backbone resolutions depending on the remaining probes available. CytoChip Cancer 8x60K has 40,000 backbone probes resulting in one probe every 80 Kb on average, CytoChip Cancer SNP 4x180K has more than 90,000 resulting in one probe every 30 Kb on average, the CytoChip 4x180K has over 150,000 backbone probes remaining with on average one probe every 20 Kb.
Complementary BlueFuse software licenses deliver fully automated array processing, including sophisticated algorithms for the identification and reporting of regions of copy number imbalance. Cancer specific tracks, now available in the cancer annotation database, aide in the interpretation of cases by comparing to progenetix, COSMIC and Mitelman databases. All results are stored in a powerful SQL database through which regions associated with specific cancer sub types or experimental endpoints may be easily identified, confirmed, exported and shared with collaborators.
See also
CytoChip Cancer SNP for details of the SNP platforms.
Applications in cancer
For Research Use Only. Not for use in diagnostic procedures
